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A hydrophobic tunnel of MmaA4 (residues 180 to 216, called 2-3 motif) protrudes from the protein surface to the cofactor binding site and covers 2 and 3 helices, and the sequence connecting 3-E displaying the same basic/hydrophobic patches as other SAM-MTs [136, 138]

Low, physiological levels of ROS are necessary for self-renew of stem cells while increased ROS levels activate proliferation, differentiation, senescence and apoptosis of stem cells in concentration-dependent manner [28]